Breast Cancer Genes

RASSF1A Polymorphism A133S Is Associated with Early Onset Breast Cancer in BRCA1/2 Mutation Carriers

http://cancerres.aacrjournals.org/cgi/content/abstract/68/1/22

Author: Ashley St John

This article is about a small-scale initial study that was testing for a correlation between RASSF1A polymorphism A133S and an early onset of breast cancer in BRCA1/2 mutation carriers. The study shows a positive correlation in people who develop breast cancer through a BRCA1/2 mutation and the RASSF1A A133S polymorphism gene. This study also showed a higher frequency of the A133S gene in people who had family history of breast cancer.

The study showed that people who had the A133S gene and the BRCA1/2 mutation had an earlier onset of breast cancer. It also showed that people who did not have the mutation but did have breast cancer also had the A133S gene. This preliminary study produced interesting results and warrants and larger study to show how strong the correlation between A133S and breast cancer.