According to Health News researches at Harvard University believe that there is additional chromosome material which causes people with Down syndrome (DS) to have a 10% risk of dying from the solid-tumour cancers. Research was conducted using the pluipotent stem cells and iPS cells from a volunteer with DS. People with the DS have a third copy of the chromosome 21; this gives rise to extra versions of the 231 genes. One of the extra versions is DSCR1 which suppressed the vascular endothelial growth factor, one of these compounds is important for angiogenesis. DSCR1 is crucial in suppressing tumour angiogenesis.
DSCR1 does not work alone there may be as much as five genes involved in angiogenesis. The DSCR1 works with another chromosome 21 gene DYRK1A to block the “calcineurin- signalling pathway” this allows the tumours to get the blood supply for growth and survival. When they target the calcineurin they suppress the ability of the endothelial cells to grow and form vessels. At this point though the role of DSCR1 in normal development is not yet fully understood. Tampering with this pathway to develop anti cancer drugs may have unintended consequences. The issue that needs to be resolved is determining any distinct differences between DSCR1’s effect on pathological versus physiological angiogenesis. The new findings can help the researchers decipher that mechanism. It is an extremely important way of looking for anti angiogenic therapy.
Posted By: S4203223
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